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NON-OPIOID TREATMENT

Humanizing pain management 

INJECTABLE

ALEVATRIX

ALEVATRIX is a preclinical investigational drug we're developing to provide postoperative pain relief for 72 hours, minimizing the need for opioid analgesics. It utilizes a patented drug delivery technology to provide a sustained therapeutic dosage of local anesthetic to the surgical site.

At Rebel, we believe no patient should have to choose between pain relief and the risk of opioid dependence. Using readily available and stable materials, we're designing ALEVATRIX to have low manufacturing and storage costs, enabling us to bring a non-opioid solution to more patients. 

WHY ALEVATRIX?

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NON-OPIOID

ALEVATRIX directly targets the nerves at the surgical site to provide pain relief without the systemic side effects experienced with opioids. 

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72-HOUR RELIEF

ALEVATRIX provides 72 hours of pain relief to patients

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REDUCE COST

ALEVATRIX has the potential to reduce the cost of surgery my minimizing opioid-related adverse events and shortening hospital stays. 

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BIOCOMPATIBLE

ALEVATRIX is composed of FDA-approved materials and is proven safe for humans 

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INJECTABLE

ALEVATRIX can be infiltrated in the surgical wound for field block or injected near a peripheral nerve for a regional block

 

WHY ALEVADERM?

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NON-OPIOID

ALEVADERM directly targets the exposed dermal nerve endings to provide pain relief without requiring systemic opioids. 

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UP TO 7 DAY DURATION

ALEVADERM's release profile can be tuned to meet various wound indications

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MOIST WOUND HEALING

ALEVADERM maintains

a moist wound microenvironment to promote natural wound healing

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BIOCOMPATIBLE

ALEVADERM is composed of materials that degrade into normal human metabolites

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MINIMIZES DRESSING CHANGE

ALEVADERM remains

on the wound until reepithelialization, reducing the pain and wound disruption that occurs with dressing changes

 
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DRESSING

ALEVADERM

ALEVADERM is a combination wound dressing in preclinical development that can deliver local anesthetics for up to 7 days. This dressing combines the ideal attributes of moist wound healing and prolonged analgesia to address the most important concerns of patients with painful wounds.

Initially targeted for painful partial-thickness wounds such as abrasions, second-degree burns and split-thickness skin graft donor sites, ALEVADERM functions as a temporary epidermal replacement controlling wound fluid and moisture to promote optimal wound healing.

Compared to existing products, this combination dressing promises greater pain control and improved clinical efficiency for the treatment of severely painful wounds.

Human-centered wound care.